NEW METHODS IN CARDIOVASCULAR BIOLOGY Multimodal SHG-2PF Imaging of Microdomain Ca2+-Contraction Coupling in Live Cardiac Myocytes
نویسندگان
چکیده
1Center for Biophotonics, UC Davis School of Medicine, University of California, Davis, 2700 Stockton Blvd., Sacramento, CA, 95817, USA; 2Pharmacology; 3Biomedical Engineering; 4Biochemistry and Molecular Medicine; 5Microsurgery Core, University of California, Davis, One Shields Ave., Davis, CA, 95616, USA; 6Division of Cardiology; 7Division of Hematology/Oncology, Department of Internal Medicine, UC Davis School of Medicine, 4150 V St., Sacramento, CA, 95817, USA, and; 8Department of Pathology and Laboratory Medicine, UC Davis School of Medicine, 4400 V St., Sacramento, CA, 95817, USA.
منابع مشابه
Multimodal SHG-2PF Imaging of Microdomain Ca2+-Contraction Coupling in Live Cardiac Myocytes.
RATIONALE Cardiac myocyte contraction is caused by Ca(2+) binding to troponin C, which triggers the cross-bridge power stroke and myofilament sliding in sarcomeres. Synchronized Ca(2+) release causes whole cell contraction and is readily observable with current microscopy techniques. However, it is unknown whether localized Ca(2+) release, such as Ca(2+) sparks and waves, can cause local sarcom...
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